There's a launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to lower afferent soreness transmission and deliver analgesia. Consequently, medications like clonidine that focus on alpha-two receptors can influence the transmission of soreness. Clonidine is distributed in breast milk; https://socials360.com/story10250379/onolidine-no-further-a-mystery