Contraindicated (one)pentobarbital will lower the extent or effect of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's Energetic metabolites. pentobarbital will lower the extent or effect of conivaptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. ... https://edwardv036mki7.salesmanwiki.com/user